Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

The first mutation associated with hypertrophic cardiomyopathy (HCM) is the R403Q mutation in the gene encoding β-myosin heavy chain (β-MyHC). R403Q locates in the globular head of myosin (S1), responsible for interaction with actin, and thus motor function of myosin. Increased cross-bridge relaxati...

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Dettagli Bibliografici
Autori principali: Witjas-Paalberends, E Rosalie, Ferrara, Claudia, Scellini, Beatrice, Piroddi, Nicoletta, Montag, Judith, Tesi, Chiara, Stienen, Ger J M, Michels, Michelle, Ho, Carolyn Y, Kraft, Theresia, Poggesi, Corrado, van der Velden, Jolanda
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146374/
https://ncbi.nlm.nih.gov/pubmed/24928957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.274571
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