Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation

The first mutation associated with hypertrophic cardiomyopathy (HCM) is the R403Q mutation in the gene encoding β-myosin heavy chain (β-MyHC). R403Q locates in the globular head of myosin (S1), responsible for interaction with actin, and thus motor function of myosin. Increased cross-bridge relaxati...

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Detalhes bibliográficos
Main Authors: Witjas-Paalberends, E Rosalie, Ferrara, Claudia, Scellini, Beatrice, Piroddi, Nicoletta, Montag, Judith, Tesi, Chiara, Stienen, Ger J M, Michels, Michelle, Ho, Carolyn Y, Kraft, Theresia, Poggesi, Corrado, van der Velden, Jolanda
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4146374/
https://ncbi.nlm.nih.gov/pubmed/24928957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.274571
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