The familial hypertrophic cardiomyopathy-associated myosin mutation R403Q accelerates tension generation and relaxation of human cardiac myofibrils

The R403Q mutation in β-myosin heavy chain was the first mutation to be identified as responsible for familial hypertrophic cardiomyopathy (FHC). In spite of extensive work on the functional sequelae of this mutation, the mechanism by which the mutant protein causes the disease has not been definite...

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Bibliographische Detailangaben
Hauptverfasser: Belus, Alexandra, Piroddi, Nicoletta, Scellini, Beatrice, Tesi, Chiara, Amati, Giulia D, Girolami, Francesca, Yacoub, Magdi, Cecchi, Franco, Olivotto, Iacopo, Poggesi, Corrado
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2008
Schlagworte:
Cardiovascular
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2538824/
https://ncbi.nlm.nih.gov/pubmed/18565996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.155952
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