Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is suffici...

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Detalhes bibliográficos
Main Authors: Nguyen, Liem H., Robinton, Daisy A., Seligson, Marc, Wu, Linwei, Li, Lin, Rakheja, Dinesh, Comerford, Sarah, Ramezani, Saleh, Sun, Xiankai, Parikh, Monisha, Yang, Erin, Powers, John T., Shinoda, Gen, Shah, Samar, Hammer, Robert, Daley, George Q., Zhu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145706/
https://ncbi.nlm.nih.gov/pubmed/25117712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.06.018
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