Polyphenolic Glycosides and Aglycones Utilize Opposing Pathways To Selectively Remodel and Inactivate Toxic Oligomers of Amyloid β

Substantial evidence suggests that soluble prefibrillar oligomers of the Aβ42 peptide associated with Alzheimer’s disease are the most cytotoxic aggregated Aβ isoform. Limited previous work has revealed that aromatic compounds capable of remodeling Aβ oligomers into non-toxic conformers typically do...

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Detalhes bibliográficos
Main Authors: Ladiwala, Ali Reza A., Mora-Pale, Mauricio, Lin, Jason C., Bale, Shyam Sundhar, Fishman, Zachary S., Dordick, Jonathan S., Tessier, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145403/
https://ncbi.nlm.nih.gov/pubmed/21671331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201100123
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