Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A(2) and Thromboxane A(2) Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response

PURPOSE: Piperine, a major alkaloid of black pepper (Piper nigrum) and long pepper (Piper longum), was shown to have anti-inflammatory activity through the suppression of cyclooxygenase (COX)-2 gene expression and enzyme activity. It is also reported to exhibit anti-platelet activity, but the mechan...

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Detalhes bibliográficos
Main Authors: Son, Dong Ju, Akiba, Satoshi, Hong, Jin Tae, Yun, Yeo Pyo, Hwang, Seock Yeon, Park, Young Hyun, Lee, Sung Eun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4145312/
https://ncbi.nlm.nih.gov/pubmed/25153972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu6083336
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