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Benzodiazepine analogues inhibit arachidonate-induced aggregation and thromboxane synthesis in human platelets.

1. Benzodiazepine analogues inhibit human platelet aggregation induced by arachidonate with an EC50 value of 0.68 microM for PK 11195, the most potent analogue used. 2. There was a highly significant correlation between the inhibition of arachidonate-induced aggregation and the affinity for the peri...

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Detalhes bibliográficos
Main Authors: Fonlupt, P., Croset, M., Lagarde, M.
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1917825/
https://ncbi.nlm.nih.gov/pubmed/1964822
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