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Increased Presence of FOXP3(+) Regulatory T Cells in Inflamed Muscle of Patients with Active Juvenile Dermatomyositis Compared to Peripheral Blood

Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4(+)CD25(+)FOXP3(+) regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored...

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Autors principals: Vercoulen, Yvonne, Bellutti Enders, Felicitas, Meerding, Jenny, Plantinga, Maud, Elst, Elisabeth F., Varsani, Hemlata, van Schieveen, Christa, Bakker, Mette H., Klein, Mark, Scholman, Rianne C., Spliet, Wim, Ricotti, Valeria, Koenen, Hans J. P. M., de Weger, Roel A., Wedderburn, Lucy R., van Royen-Kerkhof, Annet, Prakken, Berent J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144849/
https://ncbi.nlm.nih.gov/pubmed/25157414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105353
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