Role of Blimp-1 in programing Th effector cells into IL-10 producers

Secretion of the immunosuppressive cytokine interleukin (IL) 10 by effector T cells is an essential mechanism of self-limitation during infection. However, the transcriptional regulation of IL-10 expression in proinflammatory T helper (Th) 1 cells is insufficiently understood. We report a crucial ro...

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Main Authors: Neumann, Christian, Heinrich, Frederik, Neumann, Katrin, Junghans, Victoria, Mashreghi, Mir-Farzin, Ahlers, Jonas, Janke, Marko, Rudolph, Christine, Mockel-Tenbrinck, Nadine, Kühl, Anja A., Heimesaat, Markus M., Esser, Charlotte, Im, Sin-Hyeog, Radbruch, Andreas, Rutz, Sascha, Scheffold, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144744/
https://ncbi.nlm.nih.gov/pubmed/25073792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131548
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