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Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response

Interventional strategies to treat atherosclerosis, such as transluminal angioplasty and stent implantation, often cause vascular injury. This leads to intimal hyperplasia (IH) formation that induces inflammatory and fibroproliferative processes and ultimately restenosis. We show that phosphoinositi...

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Detalhes bibliográficos
Main Authors: Smirnova, Natalia F., Gayral, Stéphanie, Pedros, Christophe, Loirand, Gervaise, Vaillant, Nathalie, Malet, Nicole, Kassem, Sahar, Calise, Denis, Goudounèche, Dominique, Wymann, Matthias P., Hirsch, Emilio, Gadeau, Alain-Pierre, Martinez, Laurent O., Saoudi, Abdelhadi, Laffargue, Muriel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144742/
https://ncbi.nlm.nih.gov/pubmed/25073791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131276
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