Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response

Interventional strategies to treat atherosclerosis, such as transluminal angioplasty and stent implantation, often cause vascular injury. This leads to intimal hyperplasia (IH) formation that induces inflammatory and fibroproliferative processes and ultimately restenosis. We show that phosphoinositi...

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Autors principals: Smirnova, Natalia F., Gayral, Stéphanie, Pedros, Christophe, Loirand, Gervaise, Vaillant, Nathalie, Malet, Nicole, Kassem, Sahar, Calise, Denis, Goudounèche, Dominique, Wymann, Matthias P., Hirsch, Emilio, Gadeau, Alain-Pierre, Martinez, Laurent O., Saoudi, Abdelhadi, Laffargue, Muriel
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144742/
https://ncbi.nlm.nih.gov/pubmed/25073791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131276
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