The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation

Neutrophils are the first line of cellular defense in response to infections and inflammatory injuries. However, neutrophil activation and accumulation into tissues trigger tissue damage due to release of a plethora of toxic oxidants and proteases, a cause of acute lung injury (ALI). Despite its cli...

Full description

Saved in:
Bibliographic Details
Main Authors: Kumar, Sachin, Xu, Juying, Kumar, Rupali Sani, Lakshmikanthan, Sribalaji, Kapur, Reuben, Kofron, Matthew, Chrzanowska-Wodnicka, Magdalena, Filippi, Marie-Dominique
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144729/
https://ncbi.nlm.nih.gov/pubmed/25092872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20131706
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items