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Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reactive T cells, but their role in modulating immune responses during chronic viral infection is not well defined. To address this question and to investigate a role for T reg cells in exhaustion of virus-specific...

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Autori principali: Penaloza-MacMaster, Pablo, Kamphorst, Alice O., Wieland, Andreas, Araki, Koichi, Iyer, Smita S., West, Erin E., O’Mara, Leigh, Yang, Shu, Konieczny, Bogumila T., Sharpe, Arlene H., Freeman, Gordon J., Rudensky, Alexander Y., Ahmed, Rafi
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144726/
https://ncbi.nlm.nih.gov/pubmed/25113973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20132577
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