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Amphiphilic Nanoparticles Repress Macrophage Atherogenesis: Novel Core/Shell Designs for Scavenger Receptor Targeting and Down-Regulation

[Image: see text] Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scavenger-receptor-mediated uptake of oxidized lipoproteins (oxLDL) in macrophages. Current treatments lack the ability to directly inhibit oxLDL accumulation and foam cell conversion withi...

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Detalhes bibliográficos
Main Authors: Petersen, Latrisha K., York, Adam W., Lewis, Daniel R., Ahuja, Sonali, Uhrich, Kathryn E., Prud’homme, Robert K., Moghe, Prabhas V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144725/
https://ncbi.nlm.nih.gov/pubmed/24972372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500188g
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