REPEATED INTRANASAL APPLICATION OF NEURAL STEM CELL-MEDIATED ENZYM/PRODRUG THERAPY USING A NOVEL HSV-THYMIDINE KINASE VARIANT IMPROVES THERAPEUTIC EFFICIENCY IN AN INTRACRANIAL GLIOBLASTOMA MODEL

BACKGROUND: Neural stem cells (NSCs) have an inherent brain tumor tropism that can be exploited for targeted delivery of therapeutic genes to invasive gliomas. We have recently introduced the concept of intranasal application of NSCs as a noninvasive and direct alternative delivery method for glioma...

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Main Authors: Schmidt, Nils Ole, Dührsen, Lasse, Reitz, Matthias, Henze, Marvin, Sedlacik, Jan, Riecken, Kristoffer, Fehse, Boris, Westphal, Manfred
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144648/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.33
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