EPIGENETIC TARGETING OF HEDGEHOG PATHWAY TRANSCRIPTIONAL OUTPUT

BACKGROUND: (blind field) METHODS: We used ligand and genetic activation of the Hedgehog pathway to study the effects of BET bromodomain inhibition on Hedgehog pathway transcriptional output. Furthermore, we studied the in vitro and in vivo efficacy of BET bromodomain inhibitors using tumor cells ge...

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Main Authors: Cho, Yoon-Jae, Tang, Yujie, Schubert, Simone, Willardson, Minde, Bandopadhayay, Pratiti, Bergthold, Guillame, Nguyen, Brian, Masoud, Sabran, Vue, Nujsaubnusi, Balansay, Brianna, Gholamin, Sharareh, Cheshier, Samuel H., Atwood, Scott X., Whitson, Ramon J., Lee, Alex, Tang, Jean Y., Qi, Jun, Beroukhim, Rameen, Wechsler-Reya, Rob, Oro, Anthony E., Link, Brian, Bradner, James E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144621/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.9
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