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MICRO RNA BASED STRATEGY FOR ENHANCING THE EFFECT OF ONCOLYTIC HSV-1 VIRUS THERAPY
BACKGROUND: G47Δ is a third generation, genetically engineered, oncolytic herpes simplex virus type 1 (HSV-1) that is currently used in a clinical trial for patients with refractory glioblastomas. Genetic modifications in the γ34.5, ICP6 and α47 genes make G47Δ replicate selectively in tumor cells....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144603/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.55 |
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