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CLINICAL TRIALS OF A THIRD-GENERATION RECOMBINANT ONCOLYTIC HSV-1 IN RECURRENT GLIOBLASTOMA AND OLFACTORY NEUROBLASTOMA PATIENTS
BACKGROUND: Genetically engineered, conditionally replicating herpes simplex viruses type 1 (HSV-1) are promising therapeutic agents for cancer. We have developed a triple-mutated, third-generation oncolytic HSV-1, G47Δ, by introducing an additional genetic mutation in the viral genome of G207, a se...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144650/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou209.35 |
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