HIGH-THROUGHPUT DRUG SCREENING IDENTIFIES HDAC INHIBITORS AS CANDIDATE THERAPEUTICS FOR MYC-DRIVEN MEDULLOBLASTOMA

BACKGROUND: Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy, many patients succumb to the disease, and survivors experience severe side effects from treatment. MBs with high levels of the MYC oncogene have a particularly poor prognosis, and would benefit...

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Главные авторы: Wechsler-Reya, Robert J., Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Esparza, Lourdes A., Maier, Donna L., Li, Xiao-Nan, Cho, Yoon-Jae
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144567/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou208.22
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