EGFR PHOSPHORYLATION OF DCBLD2 RECRUITS TRAF6 AND STIMULATES AKT-PROMOTED TUMORIGENESIS

BACKGROUND: Oncogenic EGFR-Akt signaling is aberrantly activated in human glioblastomas. Discoid, CUC and LCCL domain containing protein 2 (DCBLD2, also known as CLCP1 and ESDN) is a neuropilin-like membrane protein that is up-regulated in vascular injury and metastatic lung cancers. However, the ro...

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Main Authors: Cheng, Shiyuan, Feng, Haizhong, Lopez, Giselle Y., Kim, Chung Kwon, Duncan, Christopher G., Alvarez, Angel, Nishikawa, Ryo, Nagane, Motoo, Su, An-Jey, Auron, Phillip E., Hedberg, Matthew L., Wang, Lin, Grandis, Jennifer R., McLendon, Roger E., Bigner, Darell D., Nakano, Ichiro, Joshi, Kaushal, Kim, Sunghak, Lin, Hui-Kuan, Furnari, Frank B., Cavenee, Webster K., Hu, Bo, Yan, Hai, Cheng, Shi-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144529/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.60
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