THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE IN GLIOBLASTOMA DERIVES FROM TUMOR CELLS INDEPENDENT OF STROMA

BACKGROUND: Glioma sphere-forming cells (GSCs) derived from surgical specimens are a fundamental resource to study glioblastoma (GBM) biology. Mesenchymal-expressing GSCs have been proposed as a source of treatment resistance and mesenchymal tumors correlate with poorer survival. Recently, we found...

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Main Authors: Sulman, Erik P., Wang, Qianghu, Ezhilarasan, Ravesanker, Goodman, Lindsey D., Gumen, Joy, Sun, Peng, Aldape, Ken, Alfred Yung, WK, Heffernan, Timothy, Draetta, Giulio F., Lang, Frederick F.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144493/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.28
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