TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE

Glioma sphere-forming cells (GSCs) are important in glioblastoma (GBM) initiation, maintenance, and treatment resistance. We performed whole exome and transcriptome sequencing, DNA methylation profiling, DNA copy number determination, and functional characterization of 43 GSCs and matching tumors. C...

詳細記述

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書誌詳細
出版年:Neuro Oncol
主要な著者: Wang, Qianghu, Ezhilarasan, Ravesanker, Goodman, Lindsey, Eskilsson, Eskil, Yang, Jie, Gumin, Joy, Zheng, Siyuan, Tang, Ming, Jaffari, Mona, Long, Lihong, Yoshihara, Kosuke, Sun, Peng, Heffernan, Tim, Yung, W K Alfred, Draetta, Giulio, Aldape, Kenneth, Lang, Frederick F, Verhaak, Roel, Sulman, Erik
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2017
主題:
Abstracts
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5691916/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1043
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