DRES-04. DEVELOPMENT OF A CRISPR-CAS9(D10A) TARGETABLE, HIGH-COMPLEXITY, SINGLE-CELL BARCODING APPROACH FOR ISOLATION OF TREATMENT RESISTANT SUBCLONES FROM HETEROGENOUS MALIGNANT GLIOMAS

Malignant gliomas are composed of heterogeneous cell populations and the clonal evolution of these cells is one of the key reasons for treatment resistance and tumor recurrence. A fundamental challenge in studying clonal evolution in these tumors is the difficulty in isolating the phenotype-associat...

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Publicado no:Neuro Oncol
Main Authors: Zhang, Ze-yan, Ezhilarasan, Ravesanker, Ding, Yingwen, Wang, Qianghu, Yang, Jie, Long, Lihong, Verhaak, Roel, Sulman, Erik
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692057/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.262
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