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COMPLEX EVOLUTIONARY DYNAMICS GENERATES GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN INDIVIDUAL PATIENTS WITH GLIOBLASTOMA
BACKGROUND: Glioblastoma (GB) is the most common and aggressive primary brain malignancy. The disease is advanced at the time of clinical presentation and response to treatment may be confounded by clonal heterogeneity and differential patterns of resistance in spatially distinct parts of the same t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4144488/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.23 |
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