COMPLEX EVOLUTIONARY DYNAMICS GENERATES GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN INDIVIDUAL PATIENTS WITH GLIOBLASTOMA

BACKGROUND: Glioblastoma (GB) is the most common and aggressive primary brain malignancy. The disease is advanced at the time of clinical presentation and response to treatment may be confounded by clonal heterogeneity and differential patterns of resistance in spatially distinct parts of the same t...

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Main Authors: Watts, Colin, Piccirillo, Sara, Spiteri, Inma, Sottoriva, Andrea, Touloumis, Anestis, Marioni, John, Curtis, Christina, Tavaré, Simon
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144488/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.23
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