COMPLEX EVOLUTIONARY DYNAMICS GENERATES GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN INDIVIDUAL PATIENTS WITH GLIOBLASTOMA

BACKGROUND: Glioblastoma (GB) is the most common and aggressive primary brain malignancy. The disease is advanced at the time of clinical presentation and response to treatment may be confounded by clonal heterogeneity and differential patterns of resistance in spatially distinct parts of the same t...

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Главные авторы: Watts, Colin, Piccirillo, Sara, Spiteri, Inma, Sottoriva, Andrea, Touloumis, Anestis, Marioni, John, Curtis, Christina, Tavaré, Simon
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144488/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.23
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