THE P53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA

BACKGROUND: The mechanisms driving glioblastoma (GBM) relapse remain elusive. To investigate evolutionary patterns in recurrence and therapy-resistance of GBM, we analyzed the genomic profiles from 252 primary GBM and 60 biopsy samples taken from 23 pairs of pre- and post-treatment GBM tumors. METHO...

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Main Authors: Verhaak, Roel G.W., Kim, Hoon, Zheng, Siyuan, Amini, Seyed S., Virk, Selene M., Mikkelsen, Tom, Brat, Daniel J., Grimsby, Jonna, Sougnez, Carrie, Muller, Florian, Hu, Jian, Sloan, Andrew E., Cohen, Mark L., Van Meir, Erwin G., Scarpace, Lisa, Laird, Peter W., Weinstein, John N., Lander, Eric, Gabriel, Stacey, Getz, Gad, Meyerson, Matthew, Chin, Lynda, Barnholtz-Sloan, Jill S.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144474/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou206.10
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