Targeted gene correction minimally impacts whole-genome mutational load in human disease-specific induced pluripotent stem cell clones

The utility of genome editing technologies for disease modeling and developing cellular therapies has been extensively documented, but the impact of these technologies on mutational load at the whole-genome level remains unclear. We performed whole-genome sequencing to evaluate the mutational load a...

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Detalhes bibliográficos
Main Authors: Suzuki, Keiichiro, Yu, Chang, Qu, Jing, Li, Mo, Yao, Xiaotian, Yuan, Tingting, Goebl, April, Tang, Senwei, Ren, Ruotong, Aizawa, Emi, Zhang, Fan, Xu, Xiuling, Soligalla, Rupa Devi, Chen, Feng, Kim, Jessica, Kim, Na Young, Liao, Hsin-Kai, Benner, Chris, Esteban, Concepcion Rodriguez, Jin, Yabin, Liu, Guang-Hui, Li, Yingrui, Belmonte, Juan Carlos Izpisua
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4144407/
https://ncbi.nlm.nih.gov/pubmed/24996168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.06.016
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