Choline kinase beta is required for normal endochondral bone formation

BACKGROUND: Choline kinase has three isoforms encoded by the genes Chka and Chkb. Inactivation of Chka in mice results in embryonic lethality, whereas Chkb(−/−) mice display neonatal forelimb bone deformations. METHODS: To understand the mechanisms underlying the bone deformations, we compared the b...

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Detalhes bibliográficos
Main Authors: Li, Zhuo, Wu, Gengshu, Sher, Roger B., Khavandgar, Zohreh, Hermansson, Martin, Cox, Gregory A., Doschak, Michael R., Murshed, Monzur, Beier, Frank, Vance, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143985/
https://ncbi.nlm.nih.gov/pubmed/24637075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.03.008
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