Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

Gliomas are the most common primary tumours affecting the adult central nervous system and respond poorly to standard therapy. Myc is causally implicated in most human tumours and the majority of glioblastomas have elevated Myc levels. Using the Myc dominant negative Omomyc, we previously showed tha...

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Main Authors: Annibali, Daniela, Whitfield, Jonathan R., Favuzzi, Emilia, Jauset, Toni, Serrano, Erika, Cuartas, Isabel, Redondo-Campos, Sara, Folch, Gerard, Gonzàlez-Juncà, Alba, Sodir, Nicole M., Massó-Vallés, Daniel, Beaulieu, Marie-Eve, Swigart, Lamorna B., Mc Gee, Margaret M., Somma, Maria Patrizia, Nasi, Sergio, Seoane, Joan, Evan, Gerard I., Soucek, Laura
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143920/
https://ncbi.nlm.nih.gov/pubmed/25130259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5632
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