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Evaluation of the power and type I error of recently proposed family-based tests of association for rare variants

Until very recently, few methods existed to analyze rare-variant association with binary phenotypes in complex pedigrees. We consider a set of recently proposed methods applied to the simulated and real hypertension phenotype as part of the Genetic Analysis Workshop 18. Minimal power of the methods...

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Main Authors: Hainline, Allison, Alvarez, Carolina, Luedtke, Alexander, Greco, Brian, Beck, Andrew, Tintle, Nathan L
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143711/
https://ncbi.nlm.nih.gov/pubmed/25519321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1753-6561-8-S1-S36
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