The Five-To-Six-Coordination Transition of Ferric Human Serum Heme-Albumin Is Allosterically-Modulated by Ibuprofen and Warfarin: A Combined XAS and MD Study

Human serum albumin (HSA) is involved physiologically in heme scavenging; in turn, heme-albumin (HSA-heme-Fe) displays globin-like properties. Here, the allosteric effect of ibuprofen and warfarin on the local atomic structure around the ferric heme-Fe (heme-Fe(III)) atom of HSA-heme-Fe (HSA-heme-Fe...

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Bibliographic Details
Main Authors: Meneghini, Carlo, Leboffe, Loris, Bionducci, Monica, Fanali, Gabriella, Meli, Massimiliano, Colombo, Giorgio, Fasano, Mauro, Ascenzi, Paolo, Mobilio, Settimio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143227/
https://ncbi.nlm.nih.gov/pubmed/25153171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104231
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