Protective hinge in insulin opens to enable its receptor engagement

Insulin provides a classical model of a globular protein, yet how the hormone changes conformation to engage its receptor has long been enigmatic. Interest has focused on the C-terminal B-chain segment, critical for protective self-assembly in β cells and receptor binding at target tissues. Insight...

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Autori principali: Menting, John G., Yang, Yanwu, Chan, Shu Jin, Phillips, Nelson B., Smith, Brian J., Whittaker, Jonathan, Wickramasinghe, Nalinda P., Whittaker, Linda J., Pandyarajan, Vijay, Wan, Zhu-li, Yadav, Satya P., Carroll, Julie M., Strokes, Natalie, Roberts, Charles T., Ismail-Beigi, Faramarz, Milewski, Wieslawa, Steiner, Donald F., Chauhan, Virander S., Ward, Colin W., Weiss, Michael A., Lawrence, Michael C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143003/
https://ncbi.nlm.nih.gov/pubmed/25092300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412897111
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