Use of the piggyBac Transposon to Create Stable Packaging Cell Lines for the Production of Clinical-Grade Self-Inactivating γ-Retroviral Vectors

Efforts to improve the biosafety of γ-retroviral-mediated gene therapy have resulted in a shift toward the use of self-inactivating (SIN) γ-retroviral vectors. However, scale-up and manufacturing of such vectors requires significant optimization of transient transfection-based processes or developme...

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Autors principals: Feldman, Steven A., Xu, Hui, Black, Mary A., Park, Tristen S., Robbins, Paul F., Kochenderfer, James N., Morgan, Richard A., Rosenberg, Steven A.
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc. 2014
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142856/
https://ncbi.nlm.nih.gov/pubmed/25072603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2014.071
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