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Strategies to Achieve Conditional Gene Mutation in Mice

The laboratory mouse is an ideal model organism for studying disease because it is physiologically similar to human and also because its genome is readily manipulated. Genetic engineering allows researchers to introduce specific loss-of-function or gain-of-function mutations into genes and then to s...

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Библиографические подробности
Главные авторы: Gierut, Jessica J., Jacks, Tyler E., Haigis, Kevin M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142476/
https://ncbi.nlm.nih.gov/pubmed/24692485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/pdb.top069807
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