TLR4 Activation Enhances the PD-L1-Mediated Tolerogenic Capacity of Colonic CD90(+) Stromal Cells(),()

Signaling via Programmed Death Ligand (PD-L)-1 and PD-L2 is crucial for maintaining peripheral tolerance. CD90(+) myofibroblasts/fibroblasts (CMFs) are major PD-1 ligands -expressing cells in normal human colonic mucosa. CMFs suppress activated CD4(+) T cell proliferation via PD-1 ligands. It is not...

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Main Authors: Beswick, Ellen J., Johnson, Jameel R., Saada, Jamal I., Humen, Martin, House, Jenifer, Dann, Sara, Qiu, Suimin, Brasier, Allan R., Powell, Don W., Reyes, Victor E., Pinchuk, Irina V.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142442/
https://ncbi.nlm.nih.gov/pubmed/25070848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203441
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