Expression of Programmed Death-Ligand 1 by Human Colonic CD90(+) Stromal Cells Differs Between Ulcerative Colitis and Crohn’s Disease and Determines Their Capacity to Suppress Th1 Cells

BACKGROUND AND AIMS: The role of programmed cell death protein 1 (PD-1) and its ligands in the dysregulation of T helper immune responses observed in the inflammatory bowel disease (IBD) is unclear. Recently, a novel concept emerged that CD90(+) colonic (myo)fibroblasts (CMFs), also known as stromal...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Beswick, Ellen J., Grim, Carl, Singh, Abinav, Aguirre, Jose E., Tafoya, Marissa, Qiu, Suimin, Rogler, Gerhard, McKee, Rohini, Samedi, Von, Ma, Thomas Y., Reyes, Victor E., Powell, Don W., Pinchuk, Irina V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992387/
https://ncbi.nlm.nih.gov/pubmed/29910803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01125
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