A Novel Role for CCL3 (MIP-1α) in Myeloma-induced Bone Disease via Osteocalcin Downregulation and Inhibition of Osteoblast Function

Upregulation of cytokines and chemokines is a frequent finding in multiple myeloma (MM). CCL3 (also known as MIP-1α) is a pro-inflammatory chemokine whose levels in the MM microenvironment correlate with osteolytic lesions and tumor burden. CCL3 and its receptors, CCR1 and CCR5, contribute to the de...

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Autors principals: Vallet, Sonia, Pozzi, Samantha, Patel, Kishan, Vaghela, Nileshwari, Fulciniti, MariaTeresa, Veiby, Petter, Hideshima, Teru, Santo, Loredana, Cirstea, Diana, Scadden, David T, Anderson, Kenneth C, Raje, Noopur
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142423/
https://ncbi.nlm.nih.gov/pubmed/21403648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.43
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