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Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease

Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A, a TGF-β family member, as a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased...

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Detalhes bibliográficos
Main Authors: Vallet, Sonia, Mukherjee, Siddhartha, Vaghela, Nileshwari, Hideshima, Teru, Fulciniti, Mariateresa, Pozzi, Samantha, Santo, Loredana, Cirstea, Diana, Patel, Kishan, Sohani, Aliyah R., Guimaraes, Alex, Xie, Wanling, Chauhan, Dharminder, Schoonmaker, Jesse A., Attar, Eyal, Churchill, Michael, Weller, Edie, Munshi, Nikhil, Seehra, Jasbir S., Weissleder, Ralph, Anderson, Kenneth C., Scadden, David T., Raje, Noopur
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841922/
https://ncbi.nlm.nih.gov/pubmed/20194748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911929107
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