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Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease
Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A, a TGF-β family member, as a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
National Academy of Sciences
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841922/ https://ncbi.nlm.nih.gov/pubmed/20194748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911929107 |
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