Peroxisome proliferator-activated receptor gamma (PPARG) modulates free fatty acid receptor 1 (FFAR1) dependent insulin secretion in humans

Genetic variation in FFAR1 modulates insulin secretion dependent on non-esterified fatty acid (NEFA) concentrations. We previously demonstrated lower insulin secretion in minor allele carriers of PPARG Pro12Ala in high-NEFA environment, but the mode of action could not been revealed. We tested if th...

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Autori principali: Wagner, Robert, Hieronimus, Anja, Lamprinou, Apostolia, Heni, Martin, Hatziagelaki, Erifili, Ullrich, Susanne, Stefan, Norbert, Staiger, Harald, Häring, Hans-Ulrich, Fritsche, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142395/
https://ncbi.nlm.nih.gov/pubmed/25161890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.07.001
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