Dynamical Phase Transitions Reveal Amyloid-like States on Protein Folding Landscapes

Developing an understanding of protein misfolding processes presents a crucial challenge for unlocking the mysteries of human disease. In this article, we present our observations of β-sheet-rich misfolded states on a number of protein dynamical landscapes investigated through molecular dynamics sim...

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Bibliographic Details
Main Authors: Weber, Jeffrey K., Jack, Robert L., Schwantes, Christian R., Pande, Vijay S.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2014
Subjects:
Proteins and Nucleic Acids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142240/
https://ncbi.nlm.nih.gov/pubmed/25140433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.06.046
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