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Emergence of Glass-like Behavior in Markov State Models of Protein Folding Dynamics

The extent to which glass-like kinetics govern dynamics in protein folding has been heavily debated. Here, we address the subject with an application of space-time perturbation theory to the dynamics of protein folding Markov State Models (MSMs). Borrowing techniques from the s-ensemble method, we a...

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Detalhes bibliográficos
Main Authors: Weber, Jeffrey K., Jack, Robert L., Pande, Vijay S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677858/
https://ncbi.nlm.nih.gov/pubmed/23540906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4002663
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