Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Clonally expanded mitochondrial DNA (mtDNA) mutations resulting in focal respiratory chain deficiency in individual cells are proposed to contribute to the ageing of human tissues that depend on adult stem cells for self-renewal; however, the consequences of these mutations remain unclear. A good an...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Science Ireland 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141908/
https://ncbi.nlm.nih.gov/pubmed/24915468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2014.06.003
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