Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

Clonally expanded mitochondrial DNA (mtDNA) mutations resulting in focal respiratory chain deficiency in individual cells are proposed to contribute to the ageing of human tissues that depend on adult stem cells for self-renewal; however, the consequences of these mutations remain unclear. A good an...

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Main Authors: Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science Ireland 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4141908/
https://ncbi.nlm.nih.gov/pubmed/24915468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2014.06.003
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