Mitochondrial MTHFD2L Is a Dual Redox Cofactor-specific Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase Expressed in Both Adult and Embryonic Tissues

Mammalian mitochondria are able to produce formate from one-carbon donors such as serine, glycine, and sarcosine. This pathway relies on the mitochondrial pool of tetrahydrofolate (THF) and several folate-interconverting enzymes in the mitochondrial matrix. We recently identified MTHFD2L as the enzy...

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Библиографические подробности
Главные авторы: Shin, Minhye, Bryant, Joshua D., Momb, Jessica, Appling, Dean R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2014
Предметы:
Metabolism
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140906/
https://ncbi.nlm.nih.gov/pubmed/24733394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.555573
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