CYP2W1 Is Highly Expressed in Adrenal Glands and Is Positively Associated with the Response to Mitotane in Adrenocortical Carcinoma

BACKGROUND: Adrenocortical tumors comprise frequent adenomas (ACA) and rare carcinomas (ACC). Human cytochrome P450 2W1 (CYP2W1) is highly expressed in some cancers holding the potential to activate certain drugs into tumor cytotoxins. OBJECTIVE: To investigate the CYP2W1 expression in adrenal sampl...

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Bibliografiske detaljer
Main Authors: Ronchi, Cristina L., Sbiera, Silviu, Volante, Marco, Steinhauer, Sonja, Scott-Wild, Vanessa, Altieri, Barbara, Kroiss, Matthias, Bala, Margarita, Papotti, Mauro, Deutschbein, Timo, Terzolo, Massimo, Fassnacht, Martin, Allolio, Bruno
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140842/
https://ncbi.nlm.nih.gov/pubmed/25144458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105855
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