Low SGK1 Expression in Human Adrenocortical Tumors Is Associated with ACTH-Independent Glucocorticoid Secretion and Poor Prognosis

CONTEXT: Using single-nucleotide polymorphism analysis, we observed allelic loss of the gene for serum glucocorticoid (GC) kinase 1 (SGK1), a GC-responsive kinase involved in multiple cellular functions, in a subset of cortisol-secreting adenomas. OBJECTIVE: Our objective was to analyze SGK1 express...

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Detalhes bibliográficos
Main Authors: Ronchi, Cristina L., Sbiera, Silviu, Leich, Ellen, Tissier, Frédérique, Steinhauer, Sonja, Deutschbein, Timo, Fassnacht, Martin, Allolio, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579951/
https://ncbi.nlm.nih.gov/pubmed/23055545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-2669
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