Effects of Germline CYP2W1*6 and CYP2B6*6 Single Nucleotide Polymorphisms on Mitotane Treatment in Adrenocortical Carcinoma: A Multicenter ENSAT Study

Mitotane is the only approved drug for advanced adrenocortical carcinoma (ACC) and no biomarkers are available to predict attainment of therapeutic plasma concentrations and clinical response. Aim of the study was to evaluate the suitability of cytochrome P450(CYP)2W1 and CYP2B6 single nucleotide po...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Altieri, Barbara, Sbiera, Silviu, Herterich, Sabine, De Francia, Silvia, Della Casa, Silvia, Calabrese, Anna, Pontecorvi, Alfredo, Quinkler, Marcus, Kienitz, Tina, Mannelli, Massimo, Canu, Letizia, Angelousi, Anna, Chortis, Vasileios, Kroiss, Matthias, Terzolo, Massimo, Fassnacht, Martin, Ronchi, Cristina L.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072643/
https://ncbi.nlm.nih.gov/pubmed/32033200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020359
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