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Identification and Biochemical Characterization of an Acid Sphingomyelinase-Like Protein from the Bacterial Plant Pathogen Ralstonia solanacearum that Hydrolyzes ATP to AMP but Not Sphingomyelin to Ceramide

Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine. ASMase deficiency is the underlying cause of the genetic diseases Niemann-Pick Type A and B and has been implicated in the onset and progressio...

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Detalhes bibliográficos
Main Authors: Airola, Michael V., Tumolo, Jessica M., Snider, Justin, Hannun, Yusuf A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140839/
https://ncbi.nlm.nih.gov/pubmed/25144372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105830
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