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Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5

Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was not established. In the present study, we identified...

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Bibliografski detalji
Izdano u:J Lipid Res
Glavni autori: Newcomb, Benjamin, Rhein, Cosima, Mileva, Izolda, Ahmad, Rasheed, Clarke, Christopher J., Snider, Justin, Obeid, Lina M., Hannun, Yusuf A.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6027921/
https://ncbi.nlm.nih.gov/pubmed/29724781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M084202
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